Ausbildung

Beruf

Bakr A, Siegmund M, Elsesy M, Lorat Y, Voß H, Schlüter H, Rieckmann T, Meien S, Oing C, Ruebe R, Petersen C, Rothkamm K, Mansour W. A novel role for RAP80 in DNA double-strand break end resection through targeting EXO1 to proteasome degradation. Nucleic Acid Research, submitted.

Lorat Y, Reindl J, Isermann A, Rübe C, Friedl AA, Rübe CE: Focused Ion Microbeam Irradiation Induces Clustering of DNA Double-Strand Breaks in Heterochromatin Visualized by Nanoscale-Resolution Electron Mocroscopy. International journal of molecular sciences. 2021 Jul 16;22(14):7638. doi: 10.3390/ijms22147638. PMID: 34299263.

Lorat Y, Fleckenstein J, Görlinger P, Rübe C, Rübe CE: Assessment of DNA damage by 53BP1 and pKu70 detection in peripheral blood lymphocytes by immunofluorescence and high-resolution transmission electron microscopy. Strahlentherapie und Onkologie. 2020 Jan. doi: 10.1007/s00066-020-01576-1

Timm S, Lorat Y, Jakob B, Taucher-Scholz G, Rübe CE. Clustered DNA damage concentrated in particle trajectories causes persistent large-scale rearrangements in chromatin architecture. Radiotherapy and  oncology. 2018 Dec; 129(3):600-610. Doi: 10.1016/j.radonc.2018.07.003. Epub 2018 Jul 23. PMID: 30049456.

Schuler N, Palm J, Schmitz S, Lorat Y, Rübe CE: Increasing genomic instability during cancer therapy in a patient with Li-Fraumeni syndrome. Clinical and Translational Radiation Oncology. 2017 Nov. 2:7:71. Doi: 10.1016/j.dtro.2017.10.004. eCollection 2017 Dez.

Timm S, Lorat Y, Jakob B, Taucher-Scholz G, Rübe CE: Clustered DNA damage concentrated in particle trajectories causes persistent large-scale rearrangements in chromatin architecture. Radiotherapy and Oncology. 2018 Dec;129(3):600-610. doi: 10.1016/j.radonc.2018.07.003. Epub 2018 Jul 23.

Schuler N, Palm J, Schmitz S, Lorat Y, Rübe CE: Increasing genomic instability during cancer therapy in a patient with Li-Fraumeni syndrome. Clinical and Translational Radiation Oncology. 2017 Oct. 7:71-78. https://doi.org/10.1016/j.ctro.2017.10.004

Lorat Y, Schanz S, Rübe CE: Ultrastructural insights into biological significance of persisting DNA damage foci after low doses of ionizing radiation. Clinical Cancer Research. 2016 Nov. 1; 22(21):5300-5311. PMID: 27199493

Lorat Y, Timm S, Jakob B, Taucher-Scholz G, Rübe CE. Clustered double.Strand breaks in heterochromatin perturb DNA repair after high linear energy transfer irradiation. Radiother Oncol. 2016 Oct; 121(1):154-161. doi: 10.1016/j.radonc.2016.08.028. Epub 2016 Sep 13. PMID: 27637859.

Lorat Y, Brunner CU, Schanz S, Jakob B, Taucher-Scholz G, Rübe CE: Nanoscale analysis of clustered DNA damage after high-LET irradiation by quantitative electron microscopy – the heavy burden to repair. DNA Repair (Amst). 2015 Apr; 28:93-106. doi: 10.1016/j.dnarep.2015.01.007. Epub 2015 Jan 28. PMID: 25659339.

Schanz S, Schuler N, Lorat Y, Fan L, Kaestner L, Wennemuth G, Rübe C, Rübe CE: Accumulation of DNA damage in complex normal tissues after protracted low-dose radiation. DNA Repair (Amst). 2012 Oct 1;11(10):823-32. doi: 10.1016/j.dnarep.2012.07.005. Epub 2012 Sep 1. PMID: 22947398.

Lorat Y, Schanz S, Schuler N, Wennemuth G, Rübe C, Rübe CE: Beyond repair foci: DNA double-strand break repair in euchromatic and heterochromatic sompartments analyzed by transmission electron microscopy. PLoS One. 2012;7(5):e38165. Epub 2012 May 30. NCBI-PubMed: 22666473.

Rübe CE, Lorat Y, Schuler N, Schanz S, Wennemuth G, Rübe C: DNA repair in the context of chromatin: New molecular insights by the nanoscale detection of DNA repair complexes using transmission electron microscopy. DNA Repair (Amst.) 2011 Apr 3;10(4):427-37. Epub 2011 Feb 20 ; NCBI-PubMed: 21342792.

Hauck S, Lorat Y, Leinisch F, Trommer WE: p-Nitrostilbene-tert-Butyl-Nitrone: a Novel Fluorescent Spin Trap for the Detection of ROS with Subcellular Resolution. Applied Magnetic Resonanz (2009), 36:133-147. Doi: 10.1007/s00723-009-0025-3.

Fischer A, Lenhard A, Tronecker H, Lorat Y, et. al.: iGentifier:  indexing and large-scale profiling of unknown transcriptomes. Nucleic Acid Research. 2007 Apr 18, 1-9. Doi: 10.1093/nar/gkm331.

Hauck S, Lorat Y, Leinisch F, Kopp C, Abrossinow J, Trommer WE: Fluorescent Nitrones for the Study of ROS Formation with Subcellular Resolution Nitroxides – Theory, Experiment and Application. Edited by Alexander I. Kokorin (2012). Doi: 10.5772/2887, ISBN 978-953-51-0722-4

Isermann A, Lorat Y, Mann C, Rübe CE: Histone variant H2A.J involved in persistent DNA damage signaling triggers senescence-associated inflammatory cytokine secretion. 16th international Congress of Radiation Research (ICRR), 25th – 29^th August 2019, Manchester

Timm S, Lorat Y, Jakob B, Taucher-Scholz G, Rübe CE: Clustered DNA damage concentrated in particle trajectories causes persistent large-scale rearrangements in chromatin architecture. 21. Jahrestagung der Gesellschaft für Biologische Strahlenforschung, 17.09. – 19. 09. 2018, Frankfurt am Main.

Lorat Y, Timm S, Jakob B, Taucher-Scholz G, Rübe CE: Clustering of double-strand breaks following high-LET irradiation perturbs DNA repair and is associated with long-lasting chromatin decondensation. 20. Jahrestagung der Gesellschaft für Biologische Strahlenforschung, 17.09. – 21. 09. 2017, Essen.

Lorat Y, Timm S, Brunner CU, Jakob B, Taucher-Scholz G, Rübe CE: Clustered DNA lesions induced by high-LET radiation require substantial chromatin reorganization 18. Jahrestagung der Gesellschaft für Biologische Strahlenforschung, 05.10. – 07. 10. 2015, Dresden

Lorat Y, Brunner CU, Schanz S, Jakob B, Taucher-Scholz G, Rübe CE: Nanoscale analysis of clustered DNA damage after high-LET radiation by quantitative electron microscopy - the heavy burden to repair 17. Jahrestagung der Gesellschaft für Biologische Strahlenforschung, 29.09. – 01. 10. 2014, Tübingen

Lorat Y, Brunner CU, Schanz S, Jakob B, Taucher-Scholz G, Rübe CE: Ultrastructural characterization of the DNA damage after high and low-LET radiation by transmission electron microscopy. 16. Jahrestagung der Gesellschaft für Biologische Strahlenforschung, 25. – 27. 09. 2013, Darmstadt

Lorat Y, Brunner CU, Schanz S, Jakob B, Taucher-Scholz G, Rübe CE: Ultrastructural characterization of the DNA damage after high and low-LET radiation by transmission electron microscopy. DoReMi-Conference. Contribution of epigenetic mechanisms that influence susceptibility to radiation-induced cancer. 24. – 26. 04. 2013, Stockholm, Schweden.

Lorat Y, Schanz S, Schuler N, Wennemuth Gunther, Rübe C,  Rübe CE: Beyond Repair Foci: DNA Double-strand Break Repair in Euchromatic and Heterochromatic Compartments Analyzed by Transmission Electron Microscopy. 12^th International Workshop on Radiation Damage to DNA, 02. – 07. 06. 2012, Prag, Tschechische Republik.

Lorat Y, Schuler N, Schanz S, Rübe CE: Accumulation of DNA double-strand breaks in complex normal tissues after protacted low-dose radiation exposure. 14. Jahrestagung der Gesellschaft für Biologische Strahlenforschung, 13. – 16. 09. 2011, Köln

Lorat Y, Schuler N, Schanz S, Rübe CE: DNA repair in the context of chromatin: New molecular insights by the nanoscale detection of DNA repair complexes using transmission electron microscopy. 11^th Biannual DGDR Meeting, 07. – 10. 2010, Jena.

Lorat Y, Schuler N, Schanz S, Rübe CE: DNA repair in the context of chromatin: New molecular insights by the nanoscale detection of DNA repair complexes using transmission electron microscopy. 13. Jahrestagung der Gesellschaft für Biologische Strahlenforschung, 01. – 03. 09. 2010, Hamburg

Timm S, Lorat Y, Hummel E, Jakob B, Taucher-Scholz G, Rübe CE: Repair foci comes into focus: a high-resolution microscopy analysis of the DNA-damage patterns depending on the radiation quality. 16th international Congress of Radiation Research (ICRR), 25th – 29^th August 2019, Manchester

Isermann A, Lorat Y, Mann C, Rübe CE: Histone variant H2A.J involved in persistent DNA damage signaling triggers senescence-associated inflammatory cytokine secretion. 16th international Congress of Radiation Research (ICRR), 25th – 29^th August 2019, Manchester

Lorat Y, Timm S, Jacob B, Taucher-Scholz G, Rübe CE: Clustered DNA lesions after charged-particle irradiation prevent efficient restoration of the chromatin architecture. 63rd Annual Meeting of the Radiation Research Society, 15.10. – 18. 10. 2017, Cancun, Mexico

Lorat Y, Timm S, Jacob B, Taucher-Scholz G, Rübe CE: Clustered double-strand breaks in heterochromatin perturb DNA repair after high linear energy transfer irradiation. 19. Jahrestagung der Gesellschaft für Biologische Strahlenforschung, 26.09. – 28. 09. 2016, Erlangen

Lorat Y, Schanz S, Rübe CE: Ultrastructural insights into the biological significance of persisting DNA damage foci after low doses of ionizing radiation. 18. Jahrestagung der Gesellschaft für Biologische Strahlenforschung, 05.10. – 07. 10. 2015, Dresden

Lorat Y, Brunner CU, Schanz S, Jakob B, Taucher-Scholz G, Rübe CE: Nanoscale analysis of clustered DNA damage after high-LET radiation by quantitative electron microscopy – the heavy burden to repair. 30^th Ernst Klenk Symposium in Molecular Medicine. DNA Damage Response and Repair Mechanisms in Aging and Disease, 21. – 23. 09. 2014, Köln.

Schuler S, Lorat Y, Rübe CE: Accumulation of DNA Damage-Induced Chromation Alterations in Tissue-Specific Stem Cells: The driving Force of Aging? 30^th Ernst Klenk Symposium in Molecular Medicine. DNA Damage Response and Repair Mechanisms in Aging and Disease, 21. – 23. 09. 2014, Köln.

Lorat Y, Brunner CU, Schanz S, Jakob B, Taucher-Scholz G, Rübe CE: Ku-dependent DNA double-strand break repair analyzed by transmission electron microscopy. 16. Jahrestagung der Gesellschaft für Biologische Strahlenforschung, 25. – 27. 09. 2013, Darmstadt

Lorat Y, Schanz S, Rübe CE: Accumulation of DNA damage in complex normal tissues after protacted low-dose radiation. 12^th International Workshop on Radiation Damage to DNA, 02. – 07. 06. 2012, Prag, Tschechische Republik.

Schanz S, Lorat Y, Flockerzi E, Schubeth K, Rübe CE: Genetically-defined DNA repair capacity determines extent of DNA damage accumulation in healthy tissues after very low doses of ionizing radiation. 16. Jahrestagung der Deutschen Gesellschaft für Radiologie, 07. – 10. 06. 2012, Wiesbaden.

Lorat Y, Schanz S, Schuler N, Wennemuth Gunther, Rübe C,  Rübe CE: Beyond Repair Foci: DNA Double-strand Break Repair in Euchromatic and Heterochromatic Compartments Analyzed by Transmission Electron Microscopy. 14. Jahrestagung der Gesellschaft für Biologische Strahlenforschung, 13. – 16. 09. 2012, München

Lorat Y, Schanz S, Schuler N, Wennemuth Gunther, Rübe C,  Rübe CE: Beyond Repair Foci: DNA Double-strand Break Repair in Euchromatic and Heterochromatic Compartments Analyzed by Transmission Electron Microscopy. 14. Jahrestagung der Gesellschaft für Biologische Strahlenforschung, 13. – 16. 09. 2011, Köln

Lorat Y, Schuler N, Schanz S, Rübe CE: DNA repair in the context of chromatin: New molecular insights by the nanoscale detection of DNA repair complexes using transmission electron microscopy. 13. Jahrestagung der Gesellschaft für Biol. Strahlenf., 01. – 03. 09. 2010, Hamburg.